I have a linux desktop with dual 4K screens and I don't have problems with high DPI? The only problems I've come across is with Wine which is easly fixed within the winecfg.
I'm on OpenSuSE, using KDE in X11. I DID have scaling problems with Wayland which I avoid until it is fit for daily use.
Of course 4k is 4 times 1080p (or twice in X and Y dimensions) so maybe it's much easier to scale to? 2K on the Framework is an odd resolution so maybe scaling would be more troublesome? 1080p to 1440p would be 1.3x scaling.