Correct me if I'm wrong, but I don't think pipx can allow you to just put a shebang at the top of a script that automatically installs all the required dependencies the first time you run it?
What I really like about this, unless I'm missing something, is that it basically lets you create Python scripts that run in exactly the same way as shell scripts. I work with a lot of people who have pretty good basic Linux knowledge, but are completely at a loss when it comes to python specific stuff. Being able to send them a script that they can just +x and run sounds like a huge hassle saver.