[–] 2 points 13 hours ago

This opinion piece from the BMJ entitled “The illusion of evidence based medicine” sets the stage: https://www.bmj.com/content/376/bmj.o702.

There is so much corruption and industry capture that it can be genuinely difficult to separate the real, unbiased science from “Big Pharma make number go up”. Telling people they are uneducated dipshits and to just “follow the science” ignores and further degrades the fundamental lack of trust.

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  • [–] 1 point 1 day ago

    So I’m not sure what the marginal cost per launch is. I remember reading that the propellant between Starship and Supeheavy is something like $100M per launch, which would put 20 launches at around $2B and would make the re-usability not actually a cost saver vs. an expendable rocket. However, I just read the article below that says the launch cost is more like $3-$5M, so I may have been completely off base in my original assumption.

    https://spaceorbitals.com/articles/starship-v3-cost-per-kg-2026/

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  • [–] 20 points 1 day ago (1 child)

    “OpenAI” signed the open weight pledge, which only makes sense given the company name and original values. They’ve had gpt-oss for quite a while, but it feels like a pretty half-assed effort for the purposes of virtue signaling. I’m not holding my breath for them to release an open weight model on par with GLM, Kimi, or Qwen.

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  • [–] 2 points 1 day ago

    Yeah, there’s a lot of innovation going on to run powerful models on modest hardware and the state of the art for running local models is changing all the time. If the trend continues, models hosted in a data center will only be for niche use cases.

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  • [–] 8 points 2 days ago (1 child)

    Agreed, DI in moderation can be useful. I generally like to target dependencies with I/O so they can be substituted with test doubles to allow the domain logic to be tested with fast, deterministic tests. On the other hand, I’ve seen codebases that go way overboard with SOLID and create unmaintainable messes that are difficult to reason about.

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